Useful papers

Please email me if you spot any 

Cardiovascular 

  1. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. (PRIMACORP trial-Circulation 2003)
  2. Randomised trial of RVPA conduit versus MBT shunt in single ventricle patients (Paediatric Heart Network -Single ventricle reconstruction trial)
  3. Transplantation-Free Survival and Interventions at 3 Years in the Single Ventricle Reconstruction Trial
  4. Treatment for paediatric low cardiac output syndrome: results from the European EuLoCOS-Paed survey.
  5. Management of the postoperative pediatric cardiac surgical patient. (Review-CCM-2011)
  6. The extracardiac conduit is not the preferred Fontan approach for patients with univentricular hearts. (Circulation Pro and Con debate)
  7. The extracardiac conduit is the preferred Fontan approach for patients with univentricular hearts. (Circulation Pro and Con debate)
  8. Temporary epicardial pacing after cardiac surgery: a practical review. Part 1: General considerations in the management of epicardial pacing (Pacing-review)
  9. Temporary epicardial pacing after cardiac surgery: a practical review. Part 2: Selection of epicardial pacing modes and troubleshooting.
  10. Postoperative junctional ectopic tachycardia in children: incidence, risk factors, and treatment. (JET)
  11. Estimation of Oxygen Delivery in Newborns With a Univentricular Circulation
  12. Balancing the circulation: theoretic optimization of pulmonary/systemic flow ratio in hypoplastic left heart syndrome. (Qp:Qs in HLHS)
  13. Norwood procedure for hypoplastic left heart syndrome: BT shunt or RV-PA conduit? (BCH data comparing early haemodynamics)
  14. Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome (NIRS in HLHS)
  15. Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: Results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy
  16. The Norwood procedure using a right ventricle-pulmonary artery conduit: comparison of the right-sided versus left-sided conduit position. (Right sided RVPA conduit- modified Sano-BCH paper)
  17. Development of a diagnosis- and procedure-based risk model for 30-day outcome after pediatric cardiac surgery (PRAiS Score-JTCVS-2012)
  18. Real time monitoring of risk-adjusted paediatric cardiac surgery outcomes using variable life-adjusted display: implementation in three UK centres (VLAD in cardiac surgery-Heart-2013)
  19. Failure of the Fontan circulation (2014 article)

ECMO/VAD/Transplant

  1. Prospective trial of a pediatric ventricular assist device. (Berlin Heart study-USA-NEJM-2012)
  2. A longer waiting game: bridging children to heart transplant with the Berlin Heart EXCOR device--the United Kingdom experience. (Cassidy-JHLT-2013)
  3. Berlin Heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US children

misleading or non-functioning links.

General ICU

  1. Should paediatric intensive care be centralised? Trent versus Victoria. (Gale Pearson-Lancet 1997)
  2. Paediatric index of mortality 3: an updated model for predicting mortality in pediatric intensive care
  3. Calculating the need for intensive care beds. (Gale/Fiona ADC 2012)
  4. Oxygen delivery (CCM-2003-Review article)
  5. Which inotrope and when in neonatal and paediatric intensive care? (ADC E&P 2011-Paul Baines)
  6. A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit (SAFE Study-NEJM-2004)
  7. Transfusion Strategies for Patients in Pediatric Intensive Care Units (TRIPICU study-Lacroix)
  8. Lower versus higher hemoglobin threshold for Transfusion in Septic Shock (TRISS Trial-RCT in adult ICU patients)
  9. Clonidine v Midazolam RCT-SLEEPS study (UK-2014)
  10. Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children (PEWS-Crit Care-2011)
  11. Dilemmas in undertaking research in paediatric intensive care. (Hari/Barney-ADC-2014)

Neurocritical Care & TBI

  1. Hypothermia Therapy after Traumatic Brain Injury in Children (HYPHIT trial)
  2. Decompressive Craniectomy in Diffuse Traumatic Brain Injury (DECRA trial)
  3. Guidelines for acute medical management of severe TBI in infants, children and adolescents (Brain Trauma foundation)
  4. Multimodality Monitoring in Neurocritical Care: a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine.
  5. A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury (BEST TRIP Trial -teenagers + adults with severe TBI)
  6. Increased mortality in patients with severe traumatic brain injury treated without intracranial pressure monitoring (Evidence FOR ICP targeted treatment)
  7. Continuous monitoring of cerebrovascular pressure reactivity in children (PRx in paediatric TBI-Paediatrics-2009)
  8. Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury (CPPopt measurement)
  9. THAPCA study (OHCA) Therapeutic Hypothermia after out-of-hospital cardiac arrest Moler-NEJM-2015
  10. Paediatric neurocritical care (Review-Neurotherapeutics-2012)

Respiratory

  1. Multicenter Randomized Controlled Trial of Inhaled Nitric Oxide for Pediatric Acute Respiratory Distress Syndrome
  2. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. (Meduri-Steroids in ARDS-Chest-2007)
  3. Long-term ventilation in children: longitudinal trends and outcomes (Canadian data -ADC-2013)
  4. Children on long-term ventilatory support: 10 years of progress. (UK data-ADC-2011)
  5. Neurally adjusted ventilatory assist: letting the respiratory center take over control of ventilation (NAVA editorial ICM-2013)
  6. Neurally adjusted ventilatory assist (NAVA) in pediatric intensive care—A randomized controlled trial (Ped Pulmonol 2015)
  7. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome (ARDSnet Trial NEJM 2000)
  8. UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation (Lancet 1996)
  Thanks. 

Sepsis

  1. Mortality after fluid bolus in African children with severe infection. (FEAST trial)
  2. Early goal-directed therapy in the treatment of severe sepsis and septic shock. (E Rivers-NEJM-2001)
  3. Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study
  4. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012
  5. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine.
  6. Distinct hemodynamic patterns of septic shock at presentation to pediatric intensive care. (Cold v Warm shock-Paediatrics)
  7. Goal-directed resuscitation for patients with early septic shock. (ARISE trial)
  8. A Randomized Trial of Protocol-Based Care for Early Septic Shock (PROCESS trial)
  9. Trial of early, goal-directed resuscitation for septic shock. (PROMISE trial)
  10. Early goal-directed therapy: what do we do now? (Editorial-2014)
  11. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. (SPROUT point-prevalence study in PICU-AJRCCM-2015)

Resuscitation

  1. Tight Glycemic Control versus Standard Care after Pediatric Cardiac Surgery (SPECS Study-NEJM 2012)
  2. A Randomized Trial of Hyperglycemic Control in Pediatric Intensive Care (CHiP trial-NEJM 2014)
  3. The temporal relationship between glucose-corrected serum sodium and neurological status in severe diabetic ketoacidosis. (Corrected sodium-DKA-ADC-2011)
  4. Acute Liver Failure in Children: The First 348 Patients in The Pediatric Acute Liver Failure Study Group (ALF-J Pediatrics 2006)


Organ Donation