New PICU Journalwatch collection - March 25; published - 7 April 2025

Traumatic Brain Injury and Post-Cardiac arrest care

Post-cardiac arrest care

-Barney Scholefield

Topjian AA, Zhang B, Xiao R, Fung FW, Berg RA, Graham K, et al. Multimodal monitoring including early EEG improves stratification of brain injury severity after pediatric cardiac arrest. Resuscitation. 2021;167:282-8.
Tetsuhara K, Kaku N, Watanabe Y, Kumamoto M, Ichimiya Y, Mizuguchi S, et al. Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study. Scientific reports. 2021;11(1):12090.
Lin J-J, Kuo H-C, Hsia S-H, Lin Y-J, Wang H-S, Hsu M-H, et al. The Utility of a Point-of-Care Transcranial Doppler Ultrasound Management Algorithm on Outcomes in Pediatric Asphyxial Out-of-Hospital Cardiac Arrest - An Exploratory Investigation. Frontiers in medicine. 2021;8:690405.
Kirschen MP, Majmudar T, Beaulieu F, Burnett R, Shaik M, Morgan RW, et al. Deviations from NIRS-derived optimal blood pressure are associated with worse outcomes after pediatric cardiac arrest. Resuscitation. 2021;168:110-8.
Kirschen MP, Licht DJ, Faerber J, Mondal A, Graham K, Winters M, et al. Association of MRI Brain Injury With Outcome After Pediatric Out-of-Hospital Cardiac Arrest. Neurology. 2021;96(5):e719-e31.
Kernan KF, Berger RP, Clark RSB, Scott Watson R, Angus DC, Panigrahy A, et al. An exploratory assessment of serum biomarkers of post-cardiac arrest syndrome in children. Resuscitation. 2021;167:307-16.
Laverriere EK, Polansky M, French B, Nadkarni VM, Berg RA, Topjian AA. Association of duration of hypotension with survival after pediatric cardiac arrest. Pediatric Critical Care Medicine. 2020:143-9.
Kirschen MP, Yehya N, Graham K, Kilbaugh T, Berg RA, Topjian A, et al. Circulating Neurofilament Light Chain Is Associated With Survival After Pediatric Cardiac Arrest. Pediatr Crit Care Med. 2020;21(7):656-61.
Kirschen MP, Licht DJ, Faerber J, Mondal A, Graham K, Winters M, et al. Association of MRI brain injury with outcome after pediatric out-of-hospital cardiac arrest. Neurology. 2020.
Bourgoin P, Barrault V, Joram N, Leclair Visonneau L, Toulgoat F, Anthoine E, et al. The prognostic value of early amplitude-integrated electroencephalography monitoring after pediatric cardiac arrest. Pediatric Critical Care Medicine. 2020:248-55.
Yang D, Ha SG, Ryoo E, Choi JY, Kim HJ. Multimodal assessment using early brain CT and blood pH improve prediction of neurologic outcomes after pediatric cardiac arrest. Resuscitation. 2019;137:7-13.
Sandroni C, Grippo A, Nolan JP. ERC-ESICM guidelines for prognostication after cardiac arrest: time for an update. Intensive Care Med. 2020;46(10):1901-3.
Topjian AA, Scholefield BR, Pinto NP, Fink EL, Buysse CMP, Haywood K, et al. P-COSCA (Pediatric Core Outcome Set for Cardiac Arrest) in Children: An Advisory Statement From the International Liaison Committee on Resuscitation. Resuscitation. 2021;162:351-64.
Topjian AA, de Caen A, Wainwright MS, Abella BS, Abend NS, Atkins DL, et al. Pediatric Post-Cardiac Arrest Care: A Scientific Statement From the American Heart Association. Circulation. 2019;140(6):e194-e233.
Marino BS, Tabbutt S, MacLaren G, Hazinski MF, Adatia I, Atkins DL, et al. Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association. Circulation. 2018;137(22):e691-e782.

MultiModal Monitoring

-Shruti Agrawal

Pierre Pandin, Marie Renard, Alessia Bianchini, Philippe Desjardin, Luc Van Obbergh. Monitoring Brain and Spinal Cord Metabolism and Function. DOI: 10.4236/ojanes.2014.46020
Zeiler FA, Ercole A, Cabeleira M, Beqiri E, Zoerle T, Carbonara M, Stocchetti N, Menon DK, Lazaridis C, Smielewski P, Czosnyka M; CENTER-TBI. Patient-specific ICP Epidemiologic Thresholds in Adult Traumatic Brain Injury: A CENTER-TBI Validation Study. J Neurosurg Anesthesiol. 2021;33(1):28-38. doi: 10.1097/ANA.0000000000000616. PMID: 31219937.
Casault C, Couillard P, Kromm J, Rosenthal E, Kramer A, Brindley P. Multimodal brain monitoring following traumatic brain injury: A primer for intensive care practitioners. J Intensive Care Soc. 2022;23(2):191-202. doi: 10.1177/1751143720980273. PMID: 35615230
Åkerlund CA, Donnelly J, Zeiler FA, et al.; CENTER-TBI. Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury: A CENTER-TBI high-resolution group study. PLoS One. 2020 Dec 14;15(12):e0243427. doi: 10.1371/journal.pone.0243427. PMID: 33315872; PMCID: PMC7735618.
Lazaridis C, Goldenberg FD. Intracranial Pressure in Traumatic Brain Injury: From Thresholds to Heuristics. Crit Care Med. 2020 Aug;48(8):1210-1213. doi: 10.1097/CCM.0000000000004383. PMID: 32697493.
Tas J, Beqiri E, van Kaam RC, et al. Targeting Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGiTATE): A Feasibility Randomized Controlled Clinical Trial. J Neurotrauma. 2021 Oct 15;38(20):2790-2800. doi: 10.1089/neu.2021.0197. Epub 2021 Aug 16. PMID: 34407385.
Appavu B, Temkit M', Foldes S, Burrows BT, Kuwabara M, Jacobson A, Adelson PD. Association of Outcomes with Model-Based Indices of Cerebral Autoregulation After Pediatric Traumatic Brain Injury. Neurocrit Care. 2021 Dec;35(3):640-650. doi: 10.1007/s12028-021-01279-0. Epub 2021 Jul 15. PMID: 34268644.

Illness =/= stillness

-Jessica LaRosa

Kudchadkar SR, Nelliot A, Awojoodu R, Vaidya D, Traube C, Walker T, Needham DM; Prevalence of Acute Rehabilitation for Kids in the PICU (PARK-PICU) Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Physical Rehabilitation in Critically Ill Children: A Multicenter Point Prevalence Study in the United States. Crit Care Med. 2020 May;48(5):634-644. doi: 10.1097/CCM.0000000000004291. PMID: 32168030; PMCID: PMC7539558.
LaRosa JM, Nelliot A, Zaidi M, Vaidya D, Awojoodu R, Kudchadkar SR. Mobilization Safety of Critically Ill Children. Pediatrics. 2022 Apr 1;149(4):e2021053432. doi: 10.1542/peds.2021-053432. PMID: 35352118.
Smith HAB, Besunder JB, Betters KA, et al. 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility. Pediatr Crit Care Med. 2022 Feb 1;23(2):e74-e110. doi: 10.1097/PCC.0000000000002873. PMID: 35119438.
Cuello-Garcia CA, Mai SHC, Simpson R, Al-Harbi S, Choong K. Early Mobilization in Critically Ill Children: A Systematic Review. J Pediatr. 2018 Dec;203:25-33.e6. doi: 10.1016/j.jpeds.2018.07.037. Epub 2018 Aug 29. PMID: 30172429.

ICP v CPP in TBI

-Robert Tasker

Woods KS, Horvat CM, Kantawala S, Simon DW, Rakkar J, Kochanek PM, Clark RSB, Au AK. Intracranial and Cerebral Perfusion Pressure Thresholds Associated With Inhospital Mortality Across Pediatric Neurocritical Care. Pediatr Crit Care Med. 2021;22(2):135-146. doi: 10.1097/PCC.0000000000002618. PMID: 33229873; PMCID: PMC7855782.
Kochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, Selden NR, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Wainwright MS. Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies. Pediatr Crit Care Med. 2019 Mar;20(3):269-279. doi: 10.1097/PCC.0000000000001737. PMID: 30830015.
Robertson CS. Management of cerebral perfusion pressure after traumatic brain injury. Anesthesiology. 2001 Dec;95(6):1513-7. doi: 10.1097/00000542-200112000-00034. PMID: 11748413.
Bernard F, Barsan W, Diaz-Arrastia R, Merck LH, Yeatts S, Shutter LA. Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3): a multicentre, randomised, blinded-endpoint, comparative effectiveness study of brain tissue oxygen and intracranial pressure monitoring versus intracranial pressure alone. BMJ Open. 2022 Mar 10;12(3):e060188. doi: 10.1136/bmjopen-2021-060188. PMID: 35273066; PMCID: PMC8915289.
Kochanek PM, Adelson PD, Rosario BL, et al; ADAPT Investigators. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022;5(3):e220891. doi: 10.1001/jamanetworkopen.2022.0891. PMID: 35267036; PMCID: PMC8914575.
Cooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D'Urso P, Kossmann T, Ponsford J, Seppelt I, Reilly P, Wolfe R; DECRA Trial Investigators; ANZICS CTG. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med. 2011 Apr 21;364(16):1493-502. doi: 10.1056/NEJMoa1102077. PMID: 21434843.
Newell DW, Nedergaard M, Aaslid R. Physiological Mechanisms and Significance of Intracranial B Waves. Front Neurol. 2022;13:872701. doi: 10.3389/fneur.2022.872701. PMID: 35651339; PMCID: PMC9149212.
Veenith TV, Carter EL, Geeraerts T, Grossac J, Newcombe VF, Outtrim J, Gee GS, Lupson V, Smith R, Aigbirhio FI, Fryer TD, Hong YT, Menon DK, Coles JP. Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury. JAMA Neurol. 2016;73(5):542-50. doi: 10.1001/jamaneurol.2016.0091. PMID: 27019039.
Akhondi-Asl A, Vonberg FW, Au CC, Tasker RC. Meaning of Intracranial Pressure-to-Blood Pressure Fisher-Transformed Pearson Correlation-Derived Optimal Cerebral Perfusion Pressure: Testing Empiric Utility in a Mechanistic Model. Crit Care Med. 2018 Dec;46(12):e1160-e1166. doi: 10.1097/CCM.0000000000003434. PMID: 30239383; PMCID: PMC6250242.

Page updated

Google Sites

Report abuse